Skip to main content

Some aspects of the design and analysis of cluster randomization trials

Buy Article:

$43.00 plus tax (Refund Policy)

Trials which randomize intact social groups, or clusters, to different interventions are becoming increasingly widespread. Although statistically less efficient than trials which randomize individuals, such designs are often preferred from a practical or ethical point of view, particularly in the evaluation of health care or educational strategies. We discuss selected issues that arise in the conduct of such trials, including the choice of design, ethical implications, sample size estimation and approaches to the analysis. The discussion is closely tied to methodological issues that have arisen in a recent evaluation trial of a new antenatal care programme, as sponsored by the Special Programme of Research, Development and Research Training in Human Reproduction of the World Health Organization.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Antenatal care; Clinical trials; Correlated binary data; Group randomization; Sample size estimation

Document Type: Original Article

Affiliations: University of Western Ontario, London, Canada

Publication date: 1998-01-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more