Skip to main content

Discrete Scale Models for Survival–Sacrifice Experiments

Buy Article:

$51.00 plus tax (Refund Policy)


Analyses of carcinogenicity experiments involving occult (hidden) tumours are usually based on cause-of-death information or the results of many interim sacrifices. A simple compartmental model is described that does not involve the cause of death. The method of analysis requires only one interim sacrifice, in addition to the usual terminal kill, to ensure that the tumour incidence rates can be estimated. One advantage of the approach is demonstrated in the analysis of glomerulosclerosis following exposure to ionizing radiation. Although the semiparametric model involves fewer parameters, estimates of key functions derived in this analysis are similar to those obtained previously by using a nonparametric method that involves many more parameters.

Keywords: Additive failure rate; Multiplicative failure rate; Occult tumour studies; Semiparametric model; Tumour incidence rate

Document Type: Original Article


Affiliations: 1: Health Canada, Ottawa, CA, 2: University of Waterloo, CA

Publication date: January 1, 1997

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Partial Open Access Content
Partial Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more