Discrete Scale Models for Survival–Sacrifice Experiments

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Abstract:

Analyses of carcinogenicity experiments involving occult (hidden) tumours are usually based on cause-of-death information or the results of many interim sacrifices. A simple compartmental model is described that does not involve the cause of death. The method of analysis requires only one interim sacrifice, in addition to the usual terminal kill, to ensure that the tumour incidence rates can be estimated. One advantage of the approach is demonstrated in the analysis of glomerulosclerosis following exposure to ionizing radiation. Although the semiparametric model involves fewer parameters, estimates of key functions derived in this analysis are similar to those obtained previously by using a nonparametric method that involves many more parameters.

Keywords: Additive failure rate; Multiplicative failure rate; Occult tumour studies; Semiparametric model; Tumour incidence rate

Document Type: Original Article

DOI: http://dx.doi.org/10.1111/1467-9876.00049

Affiliations: 1: Health Canada, Ottawa, CA, 2: University of Waterloo, CA

Publication date: January 1, 1997

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