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Analysis of longitudinal binary data from multiphase sampling

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The efficient use of surrogate or auxiliary information has been investigated within both model-based and design-based approaches to data analysis, particularly in the context of missing data. Here we consider the use of such data in epidemiological studies of disease incidence in which surrogate measures of disease status are available for all subjects at two time points, but definitive diagnoses are available only in stratified subsamples. We briefly review methods for the analysis of two-phase studies of disease prevalence at a single time point, and we discuss the extension of four of these methods to the analysis of incidence studies. Their performance is compared with special reference to a study of the incidence of senile dementia.

Keywords: Incidence study; Inverse probability weighting; Mean score imputation; Non-monotone missing data; Two-phase study

Document Type: Original Article


Affiliations: 1: Medical Research Council Biostatistics Unit, Cambridge, UK, 2: University of Manchester, UK, 3: Institute of Psychiatry, London, UK

Publication date: January 1, 1998


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