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Benzene Risk Estimation Using Radiation Equivalent Coefficients

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We estimated benzene risk using a novel framework of risk assessment that employed the measurement of radiation dose equivalents to benzene metabolites and a PBPK model. The highest risks for 1 g/m3 and 3.2 mg/m3 life time exposure of benzene estimated with a linear regression were 5.4 × 10−7 and 1.3 × 10−3, respectively. Even though these estimates were based on in vitro chromosome aberration test data, they were about one-sixth to one-fourteenth that from other studies and represent a fairly good estimate by using radiation equivalent coefficient as an “internal standard.”

Keywords: Benzene; PBPK model; chromosome aberration; radiation equivalent coefficient; tissue dose

Document Type: Research Article


Publication date: 2009-03-01

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