Chemical Biology & Drug Design

Chemical Biology & Drug Design 2009: Transition, Scholarship and Faith
pp. 525-526(2)
Author: Sawyer, Tomi K.

Active Site Ring-Opening of a Thiirane Moiety and Picomolar Inhibition of Gelatinases
pp. 527-534(8)
Authors: Forbes, Christopher; Shi, Qicun; Fisher, Jed F.; Lee, Mijoon; Hesek, Dusan; Llarrull, Leticia I.; Toth, Marta; Gossing, Michael; Fridman, Rafael; Mobashery, Shahriar

Synthesis, Kinetic Characterization and Metabolism of Diastereomeric 2-(1-(4-Phenoxyphenylsulfonyl)ethyl)thiiranes as Potent Gelatinase and MT1-MMP Inhibitors
pp. 535-546(12)
Authors: Gooyit, Major; Lee, Mijoon; Hesek, Dusan; Boggess, Bill; Oliver, Allen G.; Fridman, Rafael; Mobashery, Shahriar; Chang, Mayland

The Design, Synthesis and Potential Utility of Fluorescence Probes that Target DFG-out Conformation of p38α for High Throughput Screening Binding Assay
pp. 547-559(13)
Authors: Tecle, Haile; Feru, Frederic; Liu, Hu; Kuhn, Cyrille; Rennie, Glen; Morris, Mark; Shao, Jiangxing; Cheng, Alan C.; Gikunju, Diana; Miret, Juan; Coli, Rocco; Xi, Simon (Hualin); Clugston, Susan L.; Low, Simon; Kazmirski, Steven; Ding, Yuan-Hua; Cao, Qing; Johnson, Theresa L.; Deshmukh, Gayatri D.; DiNitto, Jonathan P.; Wu, Joe C.; English, Jessie M.

Analysis of c-Met Kinase Domain Complexes: A New Specific Catalytic Site Receptor Model for Defining Binding Modes of ATP-Competitive Ligands
pp. 560-570(11)
Authors: Asses, Yasmine; Leroux, Vincent; Tairi-Kellou, Safia; Dono, Rosanna; Maina, Flavio; Maigret, Bernard

Ligand-based 3D-QSAR Studies of Physostigmine Analogues as Acetylcholinesterase Inhibitors
pp. 571-581(11)
Authors: Ul-Haq, Zaheer; Mahmood, Uzma; Jehangir, Bushra

Rationalizing Protein-Ligand Interactions for PTP1B Inhibitors Using Computational Methods
pp. 582-595(14)
Authors: Ajmani, Subhash; Karanam, Sudheer; Kulkarni, Sudhir A.

Combined 3D-QSAR Modeling and Molecular Docking Study on Quinoline Derivatives as Inhibitors of P-selectin
pp. 596-610(15)
Authors: Zeng, Huahui; Cao, Ran; Zhang, Huabei

QM/MM Study of Epitope Peptides Binding to HLA-A*0201: The Roles of Anchor Residues and Water
pp. 611-618(8)
Authors: Li, Yuanchao; Yang, Yadong; He, Ping; Yang, Qingwu

Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity
pp. 619-624(6)
Authors: Beher, Dirk; Wu, John; Cumine, Suzanne; Kim, Ki Won; Lu, Shu-Chen; Atangan, Larissa; Wang, Minghan

The Anti-tumor Effects of Androstene Steroids Exhibit a Strict Structure-Activity Relationship Dependent upon the Orientation of the Hydroxyl Group on Carbon-17
pp. 625-629(5)
Authors: Graf, Martin R.; Jia, Wentao; Lewbart, Marvin L.; Loria, Roger M.

Activity Prediction and Structural Insights of Extracellular Signal-Regulated Kinase 2 Inhibitors with Molecular Dynamics Simulations
pp. 630-635(6)
Authors: Del Rio, Alberto; Baldi, Benedetta Frida; Rastelli, Giulio

Carbonic Anhydrase Inhibitors: Glycosylsulfanilamides Act as Subnanomolar Inhibitors of the Human Secreted Isoform VI
pp. 636-639(4)
Authors: Winum, Jean-Yves; Montero, Jean-Louis; Vullo, Daniela; Supuran, Claudiu T.

Calendar of Events - December 2009
pp. 640-641(2)