Home >> Journal of Neuroimaging, Volume 19, Number 3

Early Contrast-Enhanced Magnetic Resonance Imaging with Fluid-Attenuated Inversion Recovery in Multiple Sclerosis

Authors: Kataoka, Hiroshi1; Taoka, Toshiaki1; Ueno, Satoshi1

Source: Journal of Neuroimaging, Volume 19, Number 3, July 2009 , pp. 246-249(4)

Publisher: Wiley-Blackwell

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Abstract:

OBJECTIVE

Contrast-enhanced magnetic resonance imaging (MRI) with fluid-attenuated inversion recovery (contrast FLAIR) is particularly useful for the detection of meningeal lesions. However, whether contrast FLAIR is useful in multiple sclerosis (MS) remains uncertain. This study evaluated the usefulness of contrast FLAIR in MS. PATIENTS AND METHODS

We prospectively studied the clinical histories and brain MRI studies of 6 patients with clinically definite MS diagnosed according to the new McDonald criteria. Contrast FLAIR (repetition time [TR] 9,000 ms; echo time [TE] 120 ms; inversion time [TI] 2,200 ms; 5-mm slice thickness, with a 1-mm interslice gap) was obtained with the use of a bolus of gadolinium diethylenetriamine pentaacetic acid. RESULTS

Three enhancing plaques located in the periventricular or juxtacortical areas showed higher intensity on contrast FLAIR than on other MR sequences. In contrast, 8 enhancing plaques in the deep white matter or infratentorial areas showed no increased signals on contrast FLAIR. CONCLUSION

Our findings suggest that early contrast-enhanced imaging with FLAIR may be helpful for the further detection of MS plaques, particularly those located in periventricular and juxtacortical lesions.

J Neuroimaging 2009;19:246-249.

Keywords: Multiple sclerosis; FLAIR; contrast MRI

Document Type: Research article

DOI: 10.1111/j.1552-6569.2008.00315.x

Affiliations: 1: From the Department of Neurology, Nara Medical University, Kashihara, Nara, Japan (HK, SU); and Department of Radiology, Nara Medical University, Kashihara, Nara, Japan (TT).[Correction added after online publication 10-June-2009: Received and revised dates have been corrected.]

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