Event-Related fMRI of Inhibitory Control in the Predominantly Inattentive and Combined Subtypes of ADHD

Authors: Solanto, Mary V.; Schulz, Kurt P.; Fan, Jin; Tang, Cheuk Y.; Newcorn, Jeffrey H.

Source: Journal of Neuroimaging, Volume 19, Number 3, July 2009 , pp. 205-212(8)

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Abstract:

BACKGROUND AND PURPOSE

To examine the neurophysiological basis for the pronounced differences in hyperactivity and impulsiveness that distinguish the predominantly inattentive type of attention-deficit/hyperactivity disorder (ADHD-PI) from the combined type of the disorder (ADHD-C). METHODS

Event-related brain responses to a go/no-go test of inhibitory control were measured with functional magnetic resonance imaging (fMRI) in 11 children with ADHD-C and 9 children with ADHD-PI, aged 7 to 13 years, who were matched for age, sex, and intelligence. RESULTS

There were no significant group differences in task performance. Children with ADHD-C and ADHD-PI activated overlapping regions of right inferior frontal gyrus, right superior temporal lobe, and left inferior parietal lobe during inhibitory control. However, the magnitude of the activation in the temporal and parietal regions, as well as in the bilateral middle frontal gyrus, was greater in children with ADHD-PI than those with ADHD-C. Conversely, children with ADHD-C activated bilateral medial occipital lobe to a greater extent than children with ADHD-PI. CONCLUSIONS

The results provide preliminary evidence that phenotypic differences between the ADHD-C and ADHD-PI subtypes are associated with differential activation of regions that have previously been implicated in the pathophysiology of ADHD and are thought to mediate executive and attentional processes.

J Neuroimaging 2009;19:205-212.

Keywords: Attention-deficit/hyperactivity disorder; AD/HD; subtypes; inhibitory control; go/no-go; fMRI

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1552-6569.2008.00289.x

Affiliations: 1: From the Department of Psychiatry, Mount Sinai School of Medicine, New York, New York (MVS, KPS, JF, JHN); and Departments of Radiology and Psychiatry, Mount Sinai School of Medicine, New York, New York (CYT).[Correction added after online publication 10-June-2009: Received and revised dates have been corrected.]

Publication date: 2009-07-01

Event-Related fMRI of Inhibitory Control in the Predominantly Inattentive and Combined Subtypes of ADHD

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