Maximizing power in seroepidemiological studies through the use of the proportional odds model

Authors: Capuano, Ana W.¹; Dawson, Jeffrey D.²; Gray, Gregory C.¹

Source: Influenza and Other Respiratory Viruses, Volume 1, Number 3, May 2007 , pp. 87-93(7)

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Abstract:

Epidemiological studies of zoonotic influenza and other infectious diseases often rely upon analysis of levels of antibody titer. In most of these studies, the antibody titer data are dichotomized based on a chosen cut-point and analyzed with a traditional binary logistic regression. However, cut-points are often arbitrary, particularly those selected for rare diseases or for infections for which serologic assays are imperfect. Alternatively, the data can be left in the original form, as ordinal levels of antibody titer, and analyzed using the proportional odds model. We show why this approach yields superior power to detect risk factors. Additionally, we illustrate the advantages of using the proportional odds model with the analyses of zoonotic influenza antibody titer data.

Keywords: Epidemiologic methods; logistic models; models; seroepidemiological studies; statistical; statistics

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1750-2659.2007.00014.x

Affiliations: 1: Center for Emerging Infectious Diseases, Department of Epidemiology, University of Iowa College of Public Health, Coralville, IA, USA. 2: Department of Biostatistics, University of Iowa College of Public Health, Iowa City, IA, USA.

Publication date: 2007-05-01