Translocations t(X;14)(q28;q11) and t(Y;14)(q12;q11) in T-cell prolymphocytic leukemia

Authors: deOLIVEIRA, F. M.¹; TONE, L. G.²; SIMÕES, B. P.¹; REGO, E. M.¹; MARINATO, A. F.¹; JÁCOMO, R. H.¹; FALCÃO, R. P.¹

Source: International Journal of Laboratory Hematology, Volume 31, Number 4, August 2009 , pp. 453-456(4)

Publisher: Wiley-Blackwell

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Abstract:

Summary

We report a case of T-cell prolymphocytic leukemia (T-PLL) in a 41-year-old male. Classical cytogenetic, spectral karyotyping (SKY) and fluorescence in situ hybridization (FISH) studies of a blood sample obtained at diagnosis revealed the co-existence of t(X;14)(q28;q11), t(Y;14)(q12;q11) and a ring chromosome derivated from i(8)(q10). Immunophenotypic studies revealed involvement of T-cell lineage, with proliferation of CD4⁻ CD8⁺. The co-existence of two translocations involving both sex chromosomes in a case of T-PLL is rare. Chromosomal instability associated with the disease progression may have allowed the emergence of cell clones with translocations involving the sex chromosomes and the ring chromosome observed.

Keywords: t(X;14)(q28;q11) and spectral karyotyping (SKY); t(Y;14)(q12;q11); T-prolymphocytic leukemia (T-PLL) and spectral kar

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1751-553X.2008.01036.x

Affiliations: 1: Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil 2: Department of Pediatrics, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil

Publication date: 2009-08-01