Skip to main content

Modeling and Optimization in Early Detection Programs with a Single Exam

Buy Article:

$43.00 plus tax (Refund Policy)

Summary.

The choice of timing of screening examinations is an important element in determining the efficacy of strategies for the early detection of occult disease. In this article, we describe a flexible decision-making framework for the design of early detection programs, and we investigate the choice of timing when each individual in the screening program is examined only once. We focus on the theoretical relation between the optimal examination time and the distributions of sojourn times in health-related states. Specifically, we derive closed-form solutions of the optimal age using two specifications of utility functions, discuss the effects of natural history and utility specifications on the optimal solution, and present an application to early detection of colorectal cancer by once-only sigmoidoscopy or colonoscopy.
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: Chronic disease; Colorectal cancer screening; Competing risks; Decision analysis; Overdiagnosis

Document Type: Research Article

Affiliations: 1: Departments of Oncology, Biostatistics, and Pathology, Johns Hopkins University, Baltimore, Maryland 21205, U.S.A. 2: Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, U.S.A. 3: Harvard School of Public Health and Department of Biostatistical Science, Dana-Farber Cancer Institute, Boston, Massachusetts, U.S.A.

Publication date: 2002-03-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more