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Structures of a γ‐aminobutyrate (GABA) transaminase from the

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Abstract:

Two complex structures of the γ‐aminobutyrate (GABA) transaminase A1R958 from Arthrobacter aurescens TC1 are presented. The first, determined to a resolution of 2.80 Å, features the internal aldimine formed by reaction between the ɛ‐amino group of Lys295 and the cofactor pyridoxal phosphate (PLP); the second, determined to a resolution of 2.75 Å, features the external aldimine adduct formed between PLP and GABA in the first half‐reaction. This is the first structure of a microbial GABA transaminase in complex with its natural external aldimine and reveals the molecular determinants of GABA binding in this enzyme.

Document Type: Research Article

DOI: http://dx.doi.org/10.1107/S1744309112030023

Publication date: October 1, 2012

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