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Structure of d(CCGGGACCGG)

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Abstract:

The crystal structure of the decamer sequence d(CCGGGACCGG)4 has previously been reported at 2.16 Å resolution as a four‐way junction. Here, the structure of this sequence is reported at the significantly higher resolution of 1.6 Å, which is the highest resolution reported for a four‐way junction. This allowed the unambiguous identification of an extensive hydration network with distinct patterns and solvent‐mediated interactions that shed new light on the role of water in the formation and stabilization of junction structures.

Document Type: Research Article

DOI: http://dx.doi.org/10.1107/S1744309112034926

Affiliations: CAS in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai, Tamil Nadu 600 025, India

Publication date: October 1, 2012

bpl/ayf2/2012/00000068/00000010/art00006
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