Depressed adolescents in a case‐series were low in vitamin D and depression was ameliorated by vitamin D supplementation
Aim: The relationship between depression in adolescents and vitamin D was studied in a case‐series that included effects of vitamin D supplementation.
Methods: Serum 25OH vitamin D (25OHD) levels
in 54 Swedish depressed adolescents were investigated. Subjects with vitamin D deficiency were given vitamin D3 over 3 months (n = 48). To evaluate well‐being and symptoms related to depression and vitamin D status, the WHO‐5 well‐being scale,
the Mood and Feelings Questionnaire (MFQ‐S) and a vitamin D deficiency scale were used.
Results: Mean serum 25OHD in the depressed adolescents was 41 at baseline and 91 nmol/L (p < 0.001) after supplementation. Basal 25OHD levels correlated positively
with well‐being (p < 0.05). After vitamin D supplementation, well‐being increased (p < 0.001) and there was a significant improvement in eight of the nine items in the vitamin D deficiency scale: depressed feeling (p < 0.001), irritability
(p < 0.05), tiredness (p < 0.001), mood swings (p < 0.01), sleep difficulties (p < 0.01), weakness (p < 0.01), ability to concentrate (p < 0.05) and pain (p < 0.05). There was a significant amelioration
of depression according to the MFQ‐S (p < 0.05).
Conclusion: This study showed low levels of vitamin D in 54 depressed adolescents, positive correlation between vitamin D and well‐being, and improved symptoms related to depression and vitamin D deficiency
after vitamin D supplementation.
Document Type: Research Article
.Department of Molecular Medicine and Surgery, Section of Clinical Chemistry, Karolinska Institutet, Stockholm, Sweden
.Department of Molecular Medicine and Surgery, Endocrine and Diabetes Unit, Karolinska Institutet, Stockholm,Sweden
.Stockholm Child and Adolescent Psychiatry, BUP Huddinge Stockholm, Stockholm, Sweden
Publication date: July 1, 2012
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