Prepubertal follow‐up after hypospadias repair with autologous

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

Abstract

Aim:  To evaluate the long‐term effects on hypospadias repair with cultured autologous urothelial cells.

Methods:  From 2000 to 2002, six patients with scrotal or perineal hypospadias and pronounced chordee were treated surgically with cultured autologous urothelial cell transplants. All patients were evaluated at 6–8 years postoperatively, that is, in the prepubertal period. The outcome was assessed with respect to cosmetic appearance, voiding function, urinary flow, artificial erection, urethroscopy and biopsies.

Results:  Median follow‐up time was 7.25 years. Up to date, all patients present with a good cosmetic appearance. One of the boys prefers a sitting voiding position. Urinary flow curves are bell‐shaped in all but one. All have straight erections, urethroscopy reveals an even, non‐hair‐bearing surface on the transplanted side and 2/6 present with urothelial cells in biopsies. Limitations of this follow‐up study include a small group of patients and lack of controls. However, patients with severe hypospadias have high complication rates, and our results are equal or better than expected for the phenotype.

Conclusion:  Tissue engineering for severe hypospadias repair can be performed in a safe manner. The method is feasible for treatment of a selected group of hypospadias, where pronounced chordee and shortage of preputial and penile skin complicates the creation of a neourethra.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1651-2227.2012.02659.x

Affiliations:  Department of Clinical Pathology and Cytology, Division of Paediatric Pathology, Karolinska University Hospital, Stockholm, Sweden

Publication date: July 1, 2012

Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more