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Effects of naloxone on the breathing pattern of a newborn exposed to maternal opiates

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Aim:  To give new insights into how an infant responded to naloxone, given after acquiring a maternal opiate by recording the breathing pattern directly after birth.

Method:  A respiratory recording is presented of an infant during resuscitation in the delivery room after receiving naloxone for respiratory depression, resulting from maternal remifentanyl use.

Results:  The infant was born apneic and bradycardic. Normal resuscitation manoeuvres had no effect on the respiratory drive. Directly after administration of naloxone, a tachypneic breathing pattern with sporadic expiratory breaking manoeuvres was observed.

Conclusion:  The immediate tachypnoea is most likely a direct effect of the naloxone causing an immediate ‘rebound response’ after the release of the opiate‐induced inhibition of the respiratory drive.

Document Type: Research Article


Affiliations: 1: .Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands 2: .Ritchie Center, Monash University, Melbourne, Australia 3: .Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands

Publication date: July 1, 2012


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