Markers of systemic inflammation in children with hyperuricemia
Aim: The purpose of the study was to investigate serum concentrations of the monocyte chemoattractant protein‐1 (MCP‐1) and high‐sensitivity CRP (hs‐CRP) in children with hyperuricemia and to evaluate its association with obesity.
Patients and Methods: The study involved 52 hyperuricemic patients with mean age of 15.53 ± 1.7 years. Twenty‐seven healthy individuals with normal serum uric acid (SUA) level were selected as the control group (C). Serum MCP‐1 and hs‐CRP were measured by enzyme‐linked immunosorbent assay (ELISA) and immunonephelometry, respectively.
Results: Hyperuricemic patients showed increased sMCP‐1 (median: 69.58 pg/mL) and hs‐CRP (median: 0.53 mg/L) vs. controls (48.39 pg/mL, 0.24 mg/L; respectively) (p < 0.01). The obese children also presented significantly higher levels of sMCP‐1 and hs‐CRP (median, 81.69 and 1.18 mg/L, respectively) in comparison with nonobese (median, 59.62 and 0.41 mg/L, respectively; p < 0.01). Only hs‐CRP correlated positively with body mass index Z‐score (r = 0.33, p < 0.05). Receiver operator characteristic analyses checking the sensitivity and specificity of examined markers for hyperuricemia revealed the higher area under the curve (AUC) for sMCP‐1; however, the difference between AUC for sMCP‐1 and for hs‐CRP was not significant (p > 0.05).
Conclusion: Serum MCP‐1 and hs‐CRP are elevated in hyperuricemic patients, but the role of obesity in inflammation markers needs further investigation.
Document Type: Research Article
Affiliations: Department of Pediatrics and Nephrology, Medical University of Białystok, Białystok, Poland
Publication date: May 1, 2012