Skip to main content

Astrovirus and digestive disorders in neonatal units

Buy Article:

$43.00 plus tax (Refund Policy)


Aim:  To describe clinical signs associated with Human Astrovirus (HAstV) in stools in neonatal units.

Methods:  During 2005–2006, all stool virology performed for isolated digestive symptoms or suspicion of neonatal infection was tested for HAstV by an amplified enzyme‐linked immunoassay (IDEIA™ Astrovirus test, Dako Cytomation). Each newborn with a positive result (HAstV+ group) was retrospectively matched with the first following symptomatic newborn in the same care unit having a negative stool virology (HAstV− group). Clinical data were collected during two 3‐day periods (just after faecal samples collection and 1 week before) and compared within and between each group.

Results:  Human astrovirus was detected in faeces of 68 newborns [gestational age: 31.4(28.8–34) weeks] at a post‐natal age of 23 (15–42) days without seasonal dominance. Human astrovirus+ and HAstV− groups were comparable. Bloody stool (54.4% versus 14.7%, p < 0.01) and stage II–III necrotizing enterocolitis (20.6% versus 4.4%, p < 0.05) were more frequently observed in HAstV+ than in HAstV− group; these associations were confirmed by logistic regression analysis.

Conclusion:  This descriptive study argues for a possible association between HAstV and digestive symptoms in newborns specifically in preterm infants.
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Document Type: Research Article

Affiliations: 1: Department of Pediatrics CHU Rennes, Rennes, France 2: Department of Virology CHU Rennes, Rennes, France

Publication date: 2012-05-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more