Skip to main content

Bone mass development in patients with Duchenne and Becker muscular dystrophies: a 4‐year clinical follow‐up

Buy Article:

$43.00 plus tax (Refund Policy)


Aim:  To investigate the longitudinal development of bone mass in patients with Duchenne and Becker muscular dystrophies and to study the impact of muscle strength and motor function on bone mass in these patients.

Methods:  Eighteen patients with Duchenne muscular dystrophy (2.3–19.7 years at baseline) and six patients with the milder Becker muscular dystrophy (10.8–18.9 years at baseline) were followed during a 4‐year period with respect to areal bone mineral density (BMD), motor function and muscle strength.

Results:  Greater bone mineral accretion was observed in the Becker patient group compared with the age‐related Duchenne group above 10 years of age, and the older patients with Duchenne experienced decreased femoral neck BMD during the study period. In the study group, significant correlations were found between BMD in the lower extremities and muscle function parameters.

Conclusions:  The differences in BMD between patients with Duchenne and Becker as well as between different bone measurement sites demonstrated in the present study point out the importance of preserving muscle strength and motor function in patients with muscular dystrophy. Moreover; it highlights the value of performing region‐specific analysis of the bone quality in these patients.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Affiliations: 1: . Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska University Hospital/Östra, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden 2: . Bone and Mineral Metabolic Unit, Division of Clinical Chemistry, Department of Clinical and Experimental Medicine, Faculty of Health Sciences at Linköping University, Linköping, Sweden 3: . Department of Paediatrics, Institute of Clinical Sciences, The Queen Silvia Children’s Hospital, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden

Publication date: 2012-04-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more