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Systemic responses of preterm newborns with presumed or documented bacteraemia

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Aim:  To compare the frequency of elevated concentrations of inflammation‐related proteins in the blood of infants born before the 28th week of gestation who had documented bacteraemia and those who had presumed (antibiotic‐treated but culture‐negative) bacteraemia to those who had neither.

Methods:  The subjects of this study are the 868 infants born at 14 institutions for whom information about protein measurements on at least two of the three protocol days (days 1, 7, and 14) was available and who did not have Bell stage 3 necrotizing enterocolitis or isolated bowel perforation, which were strongly associated with bacteraemia in this sample.

Results:  Newborns with presumed early (week 1) bacteraemia had elevated concentrations of only a few inflammation‐related proteins, while those who had presumed late (weeks 2–4) bacteraemia did not have any elevations. In contrast, newborns who had documented early bacteraemia had a moderately strong signal, while those who had documented late bacteraemia had a stronger signal with more protein concentrations elevated on two separate occasions a week apart.

Conclusions:  Culture‐confirmed early and late bacteraemia are accompanied/followed by systemic inflammatory responses not seen with presumed early and late bacteraemia.
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Document Type: Research Article

Affiliations: 1:  Department of Neurology, Children’s Hospital Boston, and Harvard Medical School, Boston, MA, USA 2:  Division of Neonatology, Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC, USA 3:  Division of Neonatology, Department of Pediatrics, University of Massachusetts Memorial Medical Center, Worcester, MA, USA 4:  Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA 5:  Floating Hospital for Children at Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA

Publication date: 2012-04-01

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