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Neurodevelopmental outcome in full‐term newborns with refractory neonatal seizures

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Abstract

Aim:  This retrospective study describes the prognosis of full‐term newborns with refractory neonatal seizures, comparing the need for treatment with two versus three or more antiepileptic drugs.

Methods:  We reviewed our database (January 2002–December 2007) to include newborns with refractory neonatal seizures and abnormal electroencephalogram. Group A consisted of 17 newborns with two antiepileptic drugs. Group B consisted of 29 newborns with three or more antiepileptic drugs. Outcome was determined at 2 years of age using the Dutch Bayley Scales of Infant Development or a neurodevelopmental classification scheme.

Results:  Group A and group B were comparable regarding to a variety of demographic and aetiologic factors. Thirteen newborns died before 2 years of age and one was lost to follow‐up. Normal development at 2 years of age was found in 50% and 5% for group A and B, respectively. Severe neurodevelopmental delay at 2 years of age was found in 30% and 68% for group A and B, respectively.

Conclusion:  The number of antiepileptic drugs probably reflects increased seizure burden and is – in that way – related to poor outcome. This may be useful information for early prediction of adverse neurological outcome in the first days of life.
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Document Type: Research Article

Affiliations: 1:  Department of Pediatrics and Neonatology, Máxima Medical Center, Veldhoven, The Netherlands 2:  Department of Medical Psychology, Máxima Medical Center, Veldhoven, The Netherlands

Publication date: 01 April 2012

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