Skip to main content

Mouse model for men with klinefelter syndrome: a multifaceted fit for a complex disorder

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Abstract

41XXY mouse models share many characteristics of the human 47XXY Klinefelter syndrome (KS). This manuscript discusses the relative role of androgen deficiency and X chromosome genes resulting in the XXY mouse phenotype. The similarities in phenotype between 47XXY men and 41XXY mice suggest that the clinical manifestations in XXY men may be because of gene-dosage effect from genes that escape X inactivation in mouse. Conclusion: 

The 41XXY mouse is an excellent model for KS.

Keywords: Androgen deficiency; Behavioural changes; Gene over dosage; Germ cell transplantation; Klinefelter syndrome; Osteopenia

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1651-2227.2011.02149.x

Affiliations: 1: Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA, USA 2: Endocrine and Metabolic Research Program, Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia 3: Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland

Publication date: 2011-06-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more