Polymorphisms of adrenergic cardiovascular control genes are associated with adolescent chronic fatigue syndrome

$48.00 plus tax (Refund Policy)

Download / Buy Article:


Abstract Aim: 

To explore the frequency of polymorphisms in adrenergic cardiovascular control genes in adolescent with chronic fatigue syndrome (CFS) and the relation of such polymorphisms to cardiovascular variables. Methods: 

DNA from 53 patients with CFS, 12–18 years old, was analysed for five single nucleotide polymorphisms (SNPs) in the genes catechol-O-methyltransferase (COMT), the β2-adrenergic receptor (two SNPs), the β1-adrenergic receptor and the α2a-adrenergic receptor. Frequencies were compared to a reference population constructed from the National Center for Biotechnology Information (NCBI) database, and associations between frequencies and autonomic cardiovascular responses during a 20° head-uptilt-test were explored. Results: 

For the COMT SNP Rs4680, patients with CFS had a higher frequency of the AA genotype and a lower frequency of the G containing genotypes (AG and GG), when compared to the reference sample (p = 0.046). Also, the AA genotype was associated with a smaller increase in LF/HF ratio (low-frequency:high-frequency heart rate variability ratio, an index of cardiac sympathovagal balance) during head-up tilt when compared to the AG/GG genotypes. For the β2-adrenergic receptor SNP Rs1042714, patients with CFS had a lower frequency of the GG genotype and a higher frequency of the genotypes containing C (CG and CC) (p = 0.044). Conclusions: 

CFS might be related to polymorphisms of COMT and the β2-adrenergic receptor. More details of the molecular mechanisms remain to be investigated.

Keywords: Adolescents; Autonomic nervous system; Cardiovascular control genes; Chronic fatigue syndrome; Polymorphisms

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1651-2227.2010.02072.x

Affiliations: Division of Paediatrics, Oslo University Hospital, Oslo, Norway

Publication date: February 1, 2011

Related content



Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more