Skip to main content

Prevention of retinopathy of prematurity in preterm infants through changes in clinical practice and SpO2 technology

Buy Article:

$51.00 plus tax (Refund Policy)


Abstract Aim: 

To identify whether pulse oximetry technology is associated with decreased retinopathy of prematurity (ROP) and laser treatment. Methods: 

Inborn infants <1250 g who had eye exams were compared at two centres in three periods. In Period 1, SpO2 target was ≥93% and pulse oximetry technology was the same in both Centres. In Period 2, guidelines for SpO2 88–93% were implemented at both centres and Centre B changed to oximeters with signal extraction technology (SET®) while Centre A did not, but did so in Period 3. One ophthalmology department performed eye exams using international criteria. Results: 

In 571 newborns <1250 g, birth weight and gestational age were similar in the different periods and centres. At Centre A, severe ROP and need for laser remained the same in Periods 1 and 2, decreasing in Period 3–6% and 3%, respectively. At Centre B, severe ROP decreased from 12% (Period 1) to 5% (Period 2) and need for laser decreased from 5% to 3%, remaining low in Period 3. Conclusion: 

In a large group of inborn infants <1250 g, a change in clinical practice in combination with pulse oximetry with Masimo SET, but not without it, led to significant reduction in severe ROP and need for laser therapy. Pulse oximetry selection is important in managing critically ill infants.

Keywords: Hyperoxemia; Laser surgery; Newborns; Oxygen therapy; Prevention; Pulse oximetry saturation; Retinopathy of prematurity (ROP); Signal extraction technology (SET)

Document Type: Research Article


Affiliations: 1:  Northeast Georgia Medical Center, Gainesville, GA, USA 2:  Neonatal Service, Pediatrix Medical Group, Dallas, TX, USA 3:  Division of Neonatal- Perinatal Medicine, Emory University, Atlanta, GA, USA 4:  Iberoamerican Society of Neonatology, Morristown, NJ, USA

Publication date: February 1, 2011

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Partial Open Access Content
Partial Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more