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Neonatal renal vein thrombosis and prothrombotic risk

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Abstract:

Abstract

A case of extensive deep venous thrombosis in a four a day old infant was presented. Unusually this patient was shown to be heterozygous for three thrombophilia genes; Factor V Leiden, prothrombin and antithrombin gene mutations, the latter being novel. Conclusion: 

There are no randomized controlled trials to guide management in deep venous thrombosis in the newborn but knowledge of the prothrombotic risk factors may help direct treatment.

Keywords: Antithrombin gene mutation; Low molecular weight heparin; Newborn infant; Prothrombotic risk factors; Renal vein thrombosis

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1651-2227.2010.01717.x

Affiliations: 1: Neonatal Unit, Christchurch Women's Hospital, Christchurch, New Zealand 2: Department of Haematology, Canterbury District Health Board, Christchurch, New Zealand 3: Canterbury Health Laboratories, Christchurch, New Zealand 4: Department of Paediatrics, Christchurch School of Medicine, University of Otago, Christchurch, New Zealand

Publication date: July 1, 2010

bpl/apa/2010/00000099/00000007/art00030
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