Recognition and treatment of genitourinary complications in paediatric Crohn's disease using Infliximab
Source: Acta Pædiatrica, Volume 99, Number 7, July 2010 , pp. 1042-1046(5)
Abstract:Although genitourinary complications of Crohn's are well recognized, available information regarding their clinical course and management is sparse especially in the paediatric population. We report a myriad of urological complications in five paediatric cases, our experience from a tertiary paediatric urological and gastroenterological centre. All children with urological complications had severe Crohn's disease which necessitated the use of immuno-suppressants including Infliximab. Three of four children healed and closed their fistulas after treatment, although failed to avoid future surgery, albeit for other reasons. Conclusion: We suggest Infliximab should be considered as a treatment option but in the absence of a common consensus, treatment be tailored to individual cases.
Document Type: Research article
Affiliations: 1: Department of Paediatrics, Southampton University Hospital NHS Trust, Southampton, UK 2: Paediatric Urology Department, Great Ormond Street Hospital, London, UK 3: Department of Paediatric Gastroenterology, Great Ormond Street Hospital, London, UK
Publication date: 2010-07-01