Recognition and treatment of genitourinary complications in paediatric Crohn’s disease using Infliximab
Although genitourinary complications of Crohn’s are well recognized, available information regarding their clinical course and management is sparse especially in the paediatric population. We report a myriad of urological complications in five paediatric cases, our experience from a tertiary paediatric urological and gastroenterological centre. All children with urological complications had severe Crohn’s disease which necessitated the use of immuno-suppressants including Infliximab. Three of four children healed and closed their fistulas after treatment, although failed to avoid future surgery, albeit for other reasons. Conclusion:
We suggest Infliximab should be considered as a treatment option but in the absence of a common consensus, treatment be tailored to individual cases.
Document Type: Research Article
Affiliations: 1: Department of Paediatrics, Southampton University Hospital NHS Trust, Southampton, UK 2: Paediatric Urology Department, Great Ormond Street Hospital, London, UK 3: Department of Paediatric Gastroenterology, Great Ormond Street Hospital, London, UK
Publication date: July 1, 2010