Recognition and treatment of genitourinary complications in paediatric Crohn's disease using Infliximab

Authors: Afzal, NA¹; Shenoy, MU²; Haque, S²; Wilcox, DT²; Shah, N³

Source: Acta Pædiatrica, Volume 99, Number 7, July 2010 , pp. 1042-1046(5)

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Abstract:

Although genitourinary complications of Crohn's are well recognized, available information regarding their clinical course and management is sparse especially in the paediatric population. We report a myriad of urological complications in five paediatric cases, our experience from a tertiary paediatric urological and gastroenterological centre. All children with urological complications had severe Crohn's disease which necessitated the use of immuno-suppressants including Infliximab. Three of four children healed and closed their fistulas after treatment, although failed to avoid future surgery, albeit for other reasons. Conclusion:

We suggest Infliximab should be considered as a treatment option but in the absence of a common consensus, treatment be tailored to individual cases.

Keywords: Crohn's disease; Fistula; Inflammatory bowel disease; Infliximab; Nephrolithiasis; Paediatrics; Renal; Stone; Surgery; Urinary tract

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1651-2227.2010.01731.x

Affiliations: 1: Department of Paediatrics, Southampton University Hospital NHS Trust, Southampton, UK 2: Paediatric Urology Department, Great Ormond Street Hospital, London, UK 3: Department of Paediatric Gastroenterology, Great Ormond Street Hospital, London, UK

Publication date: 2010-07-01