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Prevalence and risk factors of suppurative complications in children with pneumonia

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Abstract:

Abstract Aim: 

To identify the baseline characteristics associated with suppurative complications in children with community-acquired primary pneumonia. Methods: 

A retrospective study included all children from 28 days to 15 years old, who presented with community-acquired pneumonia at two French hospitals from 1995 to 2003. Complicated pneumonia was defined by the presence of empyema and/or lung abscess. Results: 

Of 767 children with community-acquired pneumonia, 90 had suppurative complications: 83 cases of pleural empyema and seven cases of lung abscess. The mean prevalence of complicated pneumonia was 3% during the 1995–1998 period, and then steadily increased following a linear trend to reach 23% in 2003. Children with complicated pneumonia were older and had a longer symptomatic period preceding hospitalization. They were more likely to receive antibiotics, especially aminopenicillins (p<0.01), and nonsteroidal anti-inflammatory drugs, especially ibuprofen (p<0.001). In multivariable analysis, ibuprofen was the only preadmission therapy that was independently associated with complicated pneumonia [adjusted OR = 2.57 (1.51–4.35)]. Conclusion:

This study confirms an association between the use of prehospital ibruprofen and suppurative pneumonic complications.

Keywords: Children; Community-acquired pneumonia; Epidemiology; Lung abscess; Pleural empyema

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1651-2227.2010.01734.x

Affiliations: 1: Quality of Care Unit, Centre Hospitalier Universitaire de Grenoble, Grenoble, France 2: Department of Pediatrics, Centre Hospitalier Universitaire de Grenoble, Grenoble, France 3: Medical Information Department, Centre Hospitalier Universitaire de Grenoble, Grenoble, France 4: Department of Infectious Diseases, Centre Hospitalier Universitaire de Grenoble, Grenoble, France

Publication date: 2010-06-01

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