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Earlier versus later continuous Kangaroo Mother Care (KMC) for stable low-birth-weight infants: a randomized controlled trial

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Abstract Aim: 

The aim of this study was to examine the effectiveness of earlier continuous Kangaroo Mother Care (KMC) for relatively stable low-birth-weight (LBW) infants in a resource-limited country. Methods: 

A randomized controlled trial was performed in LBW infants at a referral hospital in Madagascar. Earlier continuous KMC (intervention) was begun as soon as possible, within 24 h postbirth, and later continuous KMC (control: conventional care) was begun after complete stabilization (generally after 24 h postbirth). Main outcome measure was mortality during the first 28 days postbirth. This trial was registered with, NCT00531492. Results: 

A total of 73 infants (intervention 37, control 36) were included. Earlier continuous KMC had higher but no statistically different mortality in the first 28 days postbirth (1 vs. 2; risk ratio, 1.95; 95% CIs, 0.18–20.53; p = 1.00). There were no differences in incidence of morbidities. Body weight loss from birth to 24 h postbirth was significantly less in earlier KMC infants compared with later KMC infants. (−34.81 g vs. −73.97 g; mean difference, 39.16 g; 95% CIs, 10.30–68.03; p = 0.01; adjusted p = 0.02). Adverse events and duration of hospitalization were not different between the two groups. Conclusions: 

Further evaluations of earlier continuous KMC including measurement of KMC dose, are needed in resource-limited countries.

Keywords: Kangaroo mother care; Low-birth-weight; Mortality; Randomized controlled trial; Resource-limited country

Document Type: Research Article


Affiliations: 1: .Centre Hospitalier Universitaire Mahajanga, Madagascar 2: .Osaka Medical Center and Research Institute for Maternal and Child Health, Japan 3: .Department of Health Informatics, School of Public Health, Kyoto University, Japan

Publication date: June 1, 2010


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