Allergic proctitis and abdominal distention mimicking Hirschsprung's disease in infants
Source: Acta Pædiatrica, Volume 96, Number 12, December 2007 , pp. 1784-1789(6)
Abstract:Aim: To determine the incidence and clinical aspects of allergic proctitis (AP) in infants with symptoms that mimic Hirschsprung's disease (HD).Methods: One hundred and five patients less than 6 months of age, who underwent barium enema, anorectal manometry and rectal suction biopsy due to suspicion of HD, were enrolled. Comparison of the patient characteristics associated with each disease was based on the results of the triple testing. The sensitivity and specificity of the three tests, for the diagnosis of HD, were evaluated.Results: The mean age of enrolled patients was 2.1 ± 0.9 months. Based on the three tests, 39 patients (37.1%) were diagnosed with HD, seven patients (6.7%) with AP, and 53 (50.5%) had normal results. Of the 54 patients with transitional zone and a reversed rectosigmoid index on the barium enema, four (7.4%) were patients with AP. The mean age of the AP patients (3.1 ± 1.5 months old) was older than the HD children (1.4 ± 0.9 months old). The sensitivity of the three tests for HD was 97.4%, 87.2% and 92.3% and the specificity was: 74.2%, 78.8% and 100%, respectively.Conclusions: In the infants with severe abdominal distention, the incidence of AP mimicking HD was relatively high. Therefore, consideration of AP should be part of the differential diagnosis in infants with severe abdominal distention or findings that mimic HD. For differentiation of these disorders, a rectal suction biopsy is very useful.
Document Type: Research article
Affiliations: 1: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 2: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 3: Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 4: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Publication date: 2007-12-01