Phenotype of acute respiratory syncytial virus induced lower respiratory tract illness in infancy and subsequent morbidity

Authors: Elphick, H E¹; Ritson, S¹; Rigby, A S²; Everard, M L

Source: Acta Pædiatrica, Volume 96, Number 2, February 2007 , pp. 307-309(3)

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Abstract:

The objective of this study was to investigate the association hypothesis that outcome following respiratory syncytial virus (RSV) induced bronchiolitis (RSVB) and RSV induced wheeze (RSVW) are different. At 3 years respiratory symptoms were more common in those with RSV infection than the control group but there was no increase in allergic sensitisation (11%vs 10%). Those with RSVW were more likely to have evidence of allergic sensitisation when compared with RSVB subjects (22%vs 7%), and have increased symptoms and increased use of inhaled steroids.

Conclusion: The data argue that RSV infection during infancy does not induce allergic asthma and that host factors rather than the virus determine long-term outcomes.

Keywords: Atopy; Infant; Morbidity; Phenotype; RSV; Wheeze

Document Type: Short communication

DOI: http://dx.doi.org/10.1111/j.1651-2227.2007.00082.x

Affiliations: 1: University Division of Child Health, Sheffield Children's Hospital, Sheffield, UK 2: Academic Dept of Cardiology, University of Hull, Kingston-upon-Hull, UK

Publication date: 2007-02-01