Delayed clearance of fetal lung liquid and sodium transport—genetic predisposition not evident yet

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Abstract:

Abstract

The epithelial Na+ channel (ENaC) contributes to the clearance of fetal lung liquid. In premature infants, low ENaC activity and low expression level of α‐ENaC have been associated with respiratory failure. The polymorphism in the α‐ENaC gene remains to be studied as a factor explaining the variation in the incidence of transient tachypnoea or respiratory distress syndrome in the newborn.

Conclusion

: The study of genetic predisposition to common multifactorial diseases requires analyses of large, well‐defined cohorts for representative variants of relevant candidate genes.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1651-2227.2005.tb03064.x

Affiliations: Department of Paediatrics, University of Oulu, Oulu, Finland

Publication date: March 1, 2005

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