Skip to main content

The development of ‘impervious peptides’ as growth hormone secretagogues

Buy Article:

$43.00 plus tax (Refund Policy)

The discovery and development of growth hormone (GH) secretagogues is briefly reviewed. GH‐releasing peptide‐6 (GHRP‐6) was the first GHRP to be developed that was active in vivo. Smaller peptides were found to have no GH‐releasing activity in vivo, even though they were potent releasers of GH in vitro. Substituting Trp with 2‐Me‐Trp led to the development of orally active hexarelin and other, smaller, peptides. Although they showed oral activity, absorption rarely exceeded 1% of the administered dose. Nonpeptide GH secretagogues have now been developed that combine reasonable oral absorption with high potency. The next development will be to produce GH secretagogues that overcome the lack of specificity shown by the present molecules. □ Growth hormone secretagogues, growth hormone‐releasing peptide, hexarelin
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Short Communication

Publication date: 1997-11-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more