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Effect of 6 months of growth hormone treatment in young children with Prader—Willi syndrome

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Nine prepubertal children with Prader—Willi syndrome were treated with growth hormone (GH; 24 IU/m2/week) for 6 months. Mean height increased by 0.8 SD and mean weight for height decreased by 0.7 SD over this 6‐month treatment period. Body fat, measured by dual‐energy X‐ray absorptiometry, decreased by 22.5% over the period of GH treatment, whereas fat‐free mass increased by 14%. These preliminary results indicate that GH is effective in increasing height and normalizing body composition in patients with Prader—Willi syndrome. □ Body composition, growth hormone treatment, Prader—Willi syndrome, growth

Document Type: Short Communication


Affiliations: 1: Centre for Adolescent Medicine, Zurich, Switzerland 2: Department of Medical Radiology, Nuclear Medicine, Zurich University, Zurich, Switzerland

Publication date: November 1, 1997


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