Effect of 6 months of growth hormone treatment in young children with Prader—Willi syndrome

Authors: Eiholzer, U.; Weber, R.¹; Stutz, K.¹; Steinert, H.²

Source: Acta Pædiatrica, Volume 86, Supplement 423, 1 November 1997 , pp. 66-68(3)

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Abstract:

Nine prepubertal children with Prader—Willi syndrome were treated with growth hormone (GH; 24 IU/m²/week) for 6 months. Mean height increased by 0.8 SD and mean weight for height decreased by 0.7 SD over this 6-month treatment period. Body fat, measured by dual-energy X-ray absorptiometry, decreased by 22.5% over the period of GH treatment, whereas fat-free mass increased by 14%. These preliminary results indicate that GH is effective in increasing height and normalizing body composition in patients with Prader—Willi syndrome. □ Body composition, growth hormone treatment, Prader—Willi syndrome, growth

Document Type: Short communication

DOI: http://dx.doi.org/10.1111/j.1651-2227.1997.tb18374.x

Affiliations: 1: Centre for Adolescent Medicine, Zurich, Switzerland 2: Department of Medical Radiology, Nuclear Medicine, Zurich University, Zurich, Switzerland

Publication date: 1997-11-01