Long‐term effects of intrauterine growth retardation
Authors: Kjellmer, I.; Liedholm, M.; Sultan, B.; Wennergren, M.; Götborg, C. Wallin; Thordstein, M.
Source: Acta Pædiatrica, Volume 86, Supplement 422, 1 July 1997 , pp. 83-84(2)
Abstract:Intrauterine growth retardation (IUGR) was studied both after experimental induction in rats and spontaneously occurring in man. The growth‐retarded rat pups were compared to appropriately grown litter mates with developmental and behavioural tests at 50 and 90 days of age. Female rats exhibited no differences between growth‐retarded and control rats but growth‐retarded male rats had poor performance at 50 but not at 90 days compared to male controls. In the patient study 25 growth‐retarded babies were compared with 21 appropriately grown controls. The growth‐retarded babies had delayed latency periods of the visual evoked potentials at term and 6 weeks later, and at follow‐up (18 months) demonstrated significantly more developmental and behavioural problems than the control group.
Document Type: Original Article
Affiliations: Department of Paediatrics, Department of Obstetrics and Gynaecology and Department of Physiology, University of Gôteborg, Sweden
Publication date: 1 July 1997