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Ruthenium‐Catalyzed Remote Electronic Activation of Aromatic CF Bonds

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The tandem isomerization and nucleophilic aromatic substitution of allylic fluoro‐substituted benzylic alcohols is described for the first time. In the presence of the ruthenium complex Ru(PPh3)3(CO)(H)2, 1‐(4‐fluorophenyl)prop‐2‐en‐1‐ol is converted into the corresponding para‐amino ketone or para‐phenolic substituted ketone.

Document Type: Research Article


Affiliations: 1: Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, U.K. 2: GlaxoSmithKline Research and Development, Gunnels Wood Road, Stevenage, SG1 2NY, U.K.

Publication date: March 11, 2013

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