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Rhodium‐Catalyzed Asymmetric Hydroformylation of 1,1‐Disubstituted Allylphthalimides: A Catalytic Route to β

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Abstract:

Abstract

The high enantioselective rhodium‐catalyzed hydroformylation of 1,1‐disubstituted allylphthalimides has been developed. By employing chiral ligand 1,2‐bis[(2S,5S)‐2,5‐diphenylphospholano]ethane [(S,S)‐Ph‐BPE], a series of β3‐aminoaldehydes can be prepared with up to 95% enantioselectivity. This asymmetric procedure provides an efficient alternative route to prepare chiral β3‐amino acids and alcohols.

Document Type: Communications

DOI: http://dx.doi.org/10.1002/adsc.201200960

Affiliations: 1: Department of Chemistry and Chemical Biology and Department of Pharmaceutical Chemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA, Fax: (+1)-732-445-6312 2: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, People's Republic of China

Publication date: March 11, 2013

bpl/adsc/2013/00000355/00000004/art00014
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