Nickel(II)‐Magnesium‐Catalyzed Cross‐Coupling of 1,1‐Dibromo‐1‐alkenes with Diphenylphosphine Oxide: One‐Pot Synthesis of (
A novel nickel(II)‐magnesium‐mediated cross‐coupling of diphenylphosphine oxide with a variety of 1,1‐dibromo‐1‐alkenes has been developed, which provides a powerful and general methodology for the stereoselective synthesis of various (E)‐1‐alkenylphosphine oxides or bisphosphine oxides, with operational simplicity of the procedure, good to high yields and broad substrate applicability. Mechanistic studies reveal that the reaction might involve a Hirao reduction, cross‐coupling and Michael addition.
Document Type: Communications
Affiliations: 1: Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, People's Republic of China, Fax: (+86)-592-218-5780 2: School of Pharmaceutical Science, Xiamen University, Xiamen 361005, People's Republic of China 3: Department of Chemical and Biological Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, People's Republic of China, Fax: (+86)-592-218-6198
Publication date: 2013-03-11