Ligandless Copper‐Catalyzed Coupling of Heteroaryl Bromides with Gaseous Ammonia

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A range of different N‐ and S‐containing heterocyclic bromides can be efficiently coupled with gaseous ammonia in the presence of copper(II) acetylacetonate [Cu(acac)2] as catalyst and in the absence of additional ligands. Unstable aminothiophenes and aminobenzothiophenes can be further reacted in situ to afford functionalized derivatives.

Document Type: Communications


Affiliations: Process Research & Synthesis, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland, phone: (+41)-61-687-7396, Fax: (+41)-61-688-1670

Publication date: March 11, 2013

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