Highly Stereoselective Syntheses of All 1,2,3‐

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Iridium‐catalyzed asymmetric hydrogenations of chiral alkenes were used to access four pivotal α,ω‐functionalized chirons, that contain widely occurring stereochemical 1,2,3‐Me,OH,Me motifs. A chiral analogue of Crabtree’s catalyst was used in key hydrogenation steps to form these motifs with high stereochemical purities. An application of one of these chirons is illustrated here with a synthesis of (−)‐invictolide.

Document Type: Research Article

DOI: http://dx.doi.org/10.1002/adsc.201200709

Affiliations: Department of Chemistry, Texas A& M University, Box 30012, College Station, TX 77842-3012, USA, phone: (+1)-979-845-4345, Fax: (+1)-979-845-8839

Publication date: January 14, 2013

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