Non‐Enzymatic Geometry‐Selective Acylation of Tri‐ and Tetrasubstituted α,α′‐Alkenediols
Authors: Yoshida, Keisuke; Mishiro, Kenji; Ueda, Yoshihiro; Shigeta, Takashi; Furuta, Takumi; Kawabata, Takeo
Source: Advanced Synthesis & Catalysis, Volume 354, Number 17, 26 November 2012 , pp. 3291-3298(8)
A highly geometry‐selective organocatalytic acylation of tri‐ and tetra‐substituted 2‐alkylidene‐1,3‐propanediols has been developed. The highly E‐selective acylation of various tetrasubstituted 2‐alkylidene‐1,3‐propanediols was achieved in 96 to >99% selectivity for the first time by a non‐enzymatic protocol.
Document Type: Research Article
Affiliations: Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan, phone: (+81)-774-38-3190, Fax: (+81)-774-38-3197
Publication date: 26 November 2012