Proline‐Functionalized Magnetic Core‐Shell Nanoparticles as Efficient and Recyclable Organocatalysts for Aldol Reactions
Novel magnetically tagged organocatalysts have been developed based on core‐shell nanoparticles consisting of magnetite cores and polyacrylate shells containing 4‐hydroxyproline moieties. These catalysts allow the performance of direct asymmetric aldol reactions of aromatic aldehydes with ketones in the presence of benzoic acid providing high yields and ees. Straightforward magnetic separation and recycling of a catalyst for up to 9 runs is possible without a significant loss of efficiency.
Document Type: Research Article
Affiliations: National Institute of Research and Development for Isotopic and Molecular Technologies (INCDTIM), Str. 65-103 Donath, Cluj-Napoca, Cluj, RO-400293 Romania, Fax: (+40)-264-420042
Publication date: 2012-11-26