Rhodium‐Catalyzed Asymmetric 1,4‐Additions, in Water at Room Temperature, with In‐Flask Catalyst Recycling
Using the newly introduced designer surfactant polyethylene glycol ubiquinol sebacate (PQS), as the platform for micellar catalysis, non‐racemic BINAP has been covalently attached and rhodium(I) inserted to form PQS‐BINAP‐Rh. This species, the first example of a non‐racemically‐ligated transition metal catalyst‐tethered amphiphile, can be utilized for Rh‐catalyzed asymmetric conjugate addition reactions of arylboronic acids to acyclic and cyclic enones. These are performed in water at room temperature, while the catalyst can be recycled without its removal from water in the reaction vessel.
Document Type: Communications
Affiliations: Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA, Fax: (+1)-805-893-8265
Publication date: November 26, 2012