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Palladium on Carbon‐Catalyzed Cross‐Coupling using Triarylbismuths

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Simple and efficient protocols for the 10% palladium on carbon (Pd/C)‐catalyzed cross‐coupling reactions between triarylbismuths and aryl halides have been developed. A variety of iodo‐ and bromobenzenes possessing an electron‐withdrawing group on the aromatic nucleus were smoothly cross‐coupled in the presence of 10% Pd/C, sodium phosphate dodecahydrate (Na3PO4⋅12 H2O) and 1,4‐diazabicyclo[2.2.2]octane (DABCO) in heated N‐methyl‐2‐pyrrolidone (NMP) as the solvent. For the arylations of iodobenzenes, the reactions effectively proceeded under the combined use of caesium fluoride (CsF) and 2,2′‐biquinoline. Furthermore, a ligand‐free 10% Pd/C‐catalyzed cross‐coupling reaction between the aryl iodides and triarylbismuths was also established by the addition of tetra‐n‐buthylammonium fluoride trihydrate (TBAF⋅3 H2O) in which the palladium metals were hardly leached from the catalyst into the reaction media.

Document Type: Research Article

DOI: http://dx.doi.org/10.1002/adsc.201200179

Affiliations: Laboratory of Organic Chemistry, Gifu Pharmaceutical University, Gifu 501-1196, Japan, phone: (+81)-58-230-8109, Fax: (+81)-58-230-8109

Publication date: September 17, 2012



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