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Application of Tethered Ruthenium Catalysts to Asymmetric Hydrogenation of Ketones, and the Selective Hydrogenation of Aldehydes

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Abstract:

Abstract

An improved method for the synthesis of tethered ruthenium(II) complexes of monosulfonylated diamines is described, together with their application to the hydrogenation of ketones and aldehydes. The complexes were applied directly, in their chloride form, to asymmetric ketone hydrogenation, to give products in excess of 99% ee in the best cases, using 30 bar of hydrogen at 60 °C, and to the selective reduction of aldehydes over other functional groups.

Document Type: Research Article

DOI: http://dx.doi.org/10.1002/adsc.201200362

Affiliations: 1: Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, U.K. phone (+44)-24-7652-3260, Fax: (+44)-24-7652-4112 2: Johnson Matthey Chiral Technologies, Johnson Matthey Catalysts, 28 Cambridge Science Park, Milton Road, Cambridge, CB4 0FP, U.K. 3: Johnson Matthey Chemicals India Pvt. Ltd., Plot No. 6, MIDC Industrial Estate, Taloja Dist. Raigad, Maharashtra – 410208, India

Publication date: September 17, 2012

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