Direct Catalytic Formation of Primary and Tertiary Amides from Non‐Activated Carboxylic Acids, Employing Carbamates as Amine Source
The operationally simple titanium(IV)‐ or zirconium(IV)‐catalyzed direct amidation of non‐activated carboxylic acids with ammonium carbamates generates primary, and tertiary N,N‐dimethyl‐substituted amides in good to excellent yields.
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Document Type: Research Article
Affiliations: Department of Organic Chemistry, the Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm Sweden, phone: (+46)-8-162-484, Fax: (+46)-8-154-908
Publication date: 2012-09-17