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Aluminum Triflate as a Powerful Catalyst for Direct Amination of Alcohols, Including Electron‐Withdrawing Group‐Substituted Benzhydrols

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Abstract

Direct aminations of allylic alcohols, benzylic alcohols, and benzhydrols with electron‐withdrawing (F, Br, I, NO2, or CN) substituents were efficiently catalyzed by aluminum triflate [Al(OTf)3] to afford the corresponding biarylamines in high yield, and the dibromo‐substituted product was further transformed into letrozole.
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Document Type: Communications

Affiliations: 1: Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi Higashi-ku, Fukuoka 812-8582, Japan, phone: (+81)-92-642-6650, Fax: (+81)-92-642-6650 2: Department of Chemistry, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan, phone: (+81)-6-6850-6245, Fax: (+81)-6-6850-6249

Publication date: 2012-09-17

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