Aluminum Triflate as a Powerful Catalyst for Direct Amination of Alcohols, Including Electron‐Withdrawing Group‐Substituted Benzhydrols
Direct aminations of allylic alcohols, benzylic alcohols, and benzhydrols with electron‐withdrawing (F, Br, I, NO2, or CN) substituents were efficiently catalyzed by aluminum triflate [Al(OTf)3] to afford the corresponding biarylamines in high yield, and the dibromo‐substituted product was further transformed into letrozole.
Document Type: Communications
Affiliations: 1: Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi Higashi-ku, Fukuoka 812-8582, Japan, phone: (+81)-92-642-6650, Fax: (+81)-92-642-6650 2: Department of Chemistry, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan, phone: (+81)-6-6850-6245, Fax: (+81)-6-6850-6249
Publication date: 2012-09-17