Palladium‐Catalyzed, Chelation‐Assisted Stereo‐ and Regioselective Synthesis of Tetrasubstituted Olefins by Oxidative Heck Arylation
An efficient synthesis of tetrasubstituted olefins was achieved via a palladium‐catalyzed, chelation‐assisted oxidative Heck arylation protocol from trisubstituted olefins bearing a tether with a directing group in a completely stereo‐ and regioselective manner. The stereo‐ and regioselectivity as well as excellent yields of tetrasubstituted olefins originated from the stabilization of a palladium intermediate by chelation between the palladium center and a directing group.
Document Type: Communications
Affiliations: Department of Chemistry and Institute of Basic Science, Chonnam National University, Gwangju 500-757, Republic of Korea, Fax: (+82)-62-530-3389
Publication date: September 17, 2012