Highly Diastereoselective Synthesis of Atropisomeric Bridged P,N-Ligands and Their Applications in Asymmetric Suzuki-Miyaura Coupling Reaction

Authors: Wu, Wenhao¹; Wang, Shouliang¹; Zhou, Yougui¹; He, Yuwei¹; Zhuang, Yue¹; Li, Lanning¹; Wan, Pin¹; Wang, Longshu¹; Zhou, Zhongyuan²; Qiu, Liqin¹

Source: Advanced Synthesis & Catalysis, Volume 354, Number 13, 17 September 2012 , pp. 2395-2402(8)

Publisher: Wiley-Blackwell

Buy & download fulltext article:

The full text article is not available for purchase.

The publisher only permits individual articles to be downloaded by subscribers.

Abstract:

<title type="main">Abstract</title>

Three novel atropisomeric bridged P,N-ligands were prepared using a highly efficient central-to-axial transfer strategy as the protocol. The new chiral ligands were successfully applied in the palladium-catalyzed asymmetric Suzuki-Miyaura coupling reaction, Up to 98% yield and 82% ee were obtained in the enantioselective synthesis of axially chiral biarylphosphonates.

Document Type: Communications

DOI: http://dx.doi.org/10.1002/adsc.201200095

Affiliations: 1: School of Chemistry and Chemical Engineering, Guangdong Engineering Research Center of Chiral Drugs, Sun Yat-Sen University, No. 135 Xingangxi Road, Guangzhou 510275, People's Republic of China 2: Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University,Hong Kong, People's Republic of China

Publication date: 2012-09-17