Highly Diastereoselective Synthesis of Atropisomeric Bridged P,N-Ligands and Their Applications in Asymmetric Suzuki-Miyaura Coupling Reaction
Source: Advanced Synthesis & Catalysis, Volume 354, Number 13, 17 September 2012 , pp. 2395-2402(8)
Abstract:<title type="main">Abstract</title> Three novel atropisomeric bridged P,N-ligands were prepared using a highly efficient central-to-axial transfer strategy as the protocol. The new chiral ligands were successfully applied in the palladium-catalyzed asymmetric Suzuki-Miyaura coupling reaction, Up to 98% yield and 82% ee were obtained in the enantioselective synthesis of axially chiral biarylphosphonates.
Document Type: Communications
Affiliations: 1: School of Chemistry and Chemical Engineering, Guangdong Engineering Research Center of Chiral Drugs, Sun Yat-Sen University, No. 135 Xingangxi Road, Guangzhou 510275, People's Republic of China 2: Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University,Hong Kong, People's Republic of China
Publication date: 2012-09-17