Quadri‐Synergetic Effect for Highly Effective Carbon Dioxide Fixation and Its Application to Indoloquinolinone
The first copper‐catalyzed cyclic anti‐nucleometallation–carboxylation of 2‐alkynylanilines with carbon dioxide in the presence of dimethylzinc (ZnMe2) and cesium fluoride (CsF) for the effective synthesis of indolyl‐3‐carboxylic acids and indolodihydropyran‐2‐one is described. Through a mechanistic study, it is unveiled that the metal ions Cu2+, Zn2+, Cs+ and F− are working together for this CO2‐based highly efficient carboxylation.
Document Type: Communications
Affiliations: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, People's Republic of China, Fax: (+86)-21-6260-9305
Publication date: September 17, 2012