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Synthesis of Pyrimidopyrimidinediones in a Deep Eutectic Reaction Mixture

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An efficient and general synthesis of hexahydropyrimidopyrimidinediones has been developed employing a low melting L‐(+)‐tartaric acid‐dimethylurea mixture as reaction medium. The melt acts at the same time as solvent, catalyst and reactant. Functionalized hexahydropyrimidopyrimidinediones are obtained in good to excellent yields after simple work‐up.

Document Type: Communications


Affiliations: 1: Department of Chemistry, Indian Institute of Technology Madras, Chennai – 600036, India, phone: (+91)-44-2257-4218, Fax: (+91)-44-2257-0545 2: Institut für Organische Chemie, Universität Regensburg, 93040 Regensburg, Germany, phone: (+49)-941-943-4576, Fax: (+49)-941-943-1717

Publication date: 2012-09-17

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