Authors: DeMuth, Peter C.¹; Su, Xingfang²; Samuel, Raymond E.³; Hammond, Paula T.⁴; Irvine, Darrell J.⁵

Source: Advanced Materials, Volume 22, Number 43, 16 November 2010 , pp. 4783-4783(1)

Publisher: Wiley-Blackwell

Abstract:

A new strategy to create biodegradable drug-loaded coatings on microneedle patches, using a process known as layer-by-layer (LbL) self-assembly, is reported <accessionId ref="info:doi/10.1002/adma.201001525">on p. 4851</accessionId> by Paula Hammond and coworkers. Water-soluble polymers are adsorbed with oppositely-charged drugs or drug-carrying polymer particles in alternating layers, creating extremely thin coatings loaded with high levels of entrapped drugs. These biodegradable films can be used to deposit DNA or drug-carrier nanoparticles into the skin, representing model drug cargos that could be used for vaccination or other therapeutic drug delivery. <blockFixed type="graphic"> <mediaResourceGroup> <mediaResource alt="image" href="urn:x-wiley:09359648:ADMA201090139:content" eRights="yes" copyright="WILEY-VCH"/> </mediaResourceGroup> </blockFixed>

Document Type: Research article

DOI: http://dx.doi.org/10.1002/adma.201090139

Affiliations: 1: Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (USA) 2: Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (USA) 3: Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (USA) 4: Department of Chemical Engineering and Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (USA) 5: Department of Materials Science and Engineering, Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (USA), Ragon Institute of MIT,

Publication date: 2010-11-16

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